Appendix 2
to the registration certificate АВ-05486-01-14
08/05/2015
Trifuzol 1% solution for injection
postcard-tab
Description
The solution is colorless transparent.
Composition
1 ml of solution contains the active substance:
piperidinium 2- [5- (Fursh-2-yl) -4-phenyl-1,2,4-triazol-3-ylggio] acetate 10.0 mg,
Excipients: sodium chloride, water for injection.
Pharmacological properties
АТС vet classification code: QL03AX Other immunostimulants.
The active substance of the drug belongs to triazole derivatives. The mechanism of action of the active substance consists in the activation of biochemical processes in tissue cells. The drug has antioxidant, immunomodulatory, anti-inflammatory, hepatoprotective and detoxifying effects, normalizes metabolism, enhances the specific immune response to vaccines, increases the body’s resistance to diseases of viral etiology, helps restore specific and nonspecific resistance indicators, increase the content of T-cells, B-lymphocytes blood.
The active substance is excreted from the body 24 hours after the last application and is not detected in the blood serum.
Application
In the complex treatment of dogs, cats with purulent-inflammatory diseases (wounds, abscesses, etc.) to accelerate reparative processes, recovery of animals, activation of natural defense factors of the body.
The drug is used in chickens, rearing laying hens to improve the overall resistance of the body, activate the specific immune response to vaccines, and reduce post-vaccination complications.
For complex therapy in the treatment of cows with purulent-necrotic skin processes, surgical wounds and abscesses.
To newborn piglets in order to prevent the occurrence of diseases and to increase the growth of young animals.
Dosage
Intramuscularly administered to dogs, cats at a dose of 1 ml per 10 kg of body weight for 3-5 days. For local treatment of animals, the drug is applied to open wounds along with etiotropic agents.
To enhance the specific immune response of poultry, the drug is added to drinking water for drinking within two days before and two days after vaccination at the rate of 0.5 ml per 10 kg of body weight for 1 day or 1 liter of the drug per 1 ton of drinking water.
In cows, the drug is administered intramuscularly in the complex therapy of purulent-inflammatory processes after surgery at a dose of 1-1.5 ml per 10 kg of body weight (1-1.5 mg per 1 kg of body weight) twice with an interval of 48-72 hours.
For newborn piglets, the drug is used twice on the first and seventh days of life intramuscularly in the neck at a dose of 1-1.5 ml per 10 kg of body weight (1-1.5 mg per 1 kg of body weight), which helps to reduce the possibility of diseases, reduce the severity of the course of the pathology, increase in growth until the moment of weaning from the sow.
Side effect
Isolated cases (up to 1%) of allergic manifestations in dogs and cats in the form of hyperemia and itching of the skin. Very rarely, vomiting may occur.
Caution when using
An aqueous solution of the drug must be used on the day of preparation.
Withdrawal period
When using the drug according to the indicated scheme, the active substance and its decay products were not found in poultry meat.
Meat of cows and pigs, milk, eggs – 28 days.
Upon receipt of products before the specified period, they are disposed of or fed to unproductive animals, according to the conclusion of a veterinarian.
Issue form
Glass bottles, 20, 50 and 100 ml.
Storage
Dry, protected from light place at a temperature of 4 to 25 ° C.
An aqueous solution of the drug must be used on the day of preparation.
Shelf life – 2 years.
For use in veterinary medicine!
Name and location of the marketing authorization holder:
OOO NPP Lugfarma
st. Kurchatova, d. 6, of. 9, Lugansk, Lugansk region, 91031, Ukraine
Manufacturer name and location:
Kharkiv State Biological Factory
per. Rustaveli, 4, Kharkov, Kharkov region, 61050, Ukraine
Appendix 1
to registration certificate АВ-05486-01-14
08/05/2015
Brief description of the preparation
- Title
Trifusol 1% solution for injection
- Composition
1 ml of solution contains the active substance:
piperidinium 2- [5- (furan-2-yl) -4-feyuya-], 2,4-triazol-3-ylthio] acetate 10.0mg.
Excipients: sodium chloride, water for injection.
- Pharmaceutical (dosage) form
Injection.
- Pharmacological properties
АТС vet classification code: QL03AX Other immunostimulants.
The active substance of the drug belongs to triazole derivatives. The mechanism of action of the active substance consists in the activation of biochemical processes in tissue cells. The drug has antioxidant, immunomodulatory, anti-inflammatory, hepatoprotective and detoxifying effects, normalizes metabolism, enhances the specific immune response to vaccines, increases the body’s resistance to diseases of viral etiology, helps restore specific and nonspecific resistance indicators, increase the content of T-cells, B-lymphocytes blood.
The active substance is excreted from the body 24 hours after the last application and is not detected in the blood serum.
- Clinical features.
5.1 Species
Cattle, pigs, dogs, cats, chickens, laying hens.
5.2 Indications for use
In the complex treatment of dogs, cats with purulent-inflammatory diseases (wounds, abscesses, etc.) to accelerate reparative processes, animal recovery, activation of the body’s natural defense factors.
The drug is used in chickens, rearing laying hens to improve the overall resistance of the organism, activate the specific immune response to the introduction of vaccines, and reduce post-vaccination complications.
In complex therapy in the treatment of cows with purulent-necrotic skin processes, surgical wounds and abscesses.
To newborn piglets in order to prevent the occurrence of diseases and to increase the growth of young animals.
5.3 Contraindications
No data.
5.4 Side effects
Isolated cases (up to 1%) of allergic manifestations in dogs and cats in the form of hyperemia and itching of the skin. Very rarely, vomiting may occur.
5.5 Special precautions for use
For oral administration, the drug must be diluted with water before use.
5.6 Use during pregnancy, lactation, egg production
No data.
5.7 Interaction with other tools and other forms of interaction
Enhances specific immune response to vaccines.
5.8 Doses and routes of administration to animals of different ages
Intramuscularly administered to dogs, cats at a dose of 1 ml of the drug per 10 kg of body weight for 3-5 days. For local treatment of animals, the drug is applied to open wounds along with etiotropic agents.
To enhance the specific immune response of poultry, the drug is added to drinking water for drinking within two days before and two days after vaccination at the rate of 0.5 ml per 10 kg of body weight for 1 day or 1 liter of the drug per 1 ton of drinking water.
In cows, the drug is administered intramuscularly as part of complex therapy for purulent-inflammatory processes after surgical interventions at a dose of 1-1.5 ml per 10 kg of body weight (1-1.5 mg per 1 kg of body weight) twice with an interval of 48-72 hours.
For newborn piglets, the drug is used twice on the first and seventh days of life intramuscularly in the neck at a dose of 1-1.5 ml per 10 kg of body weight (1-1.5 mg per 1 kg of body weight), which helps to reduce the possibility of diseases, reduce the severity of the course of the pathology, the increase in growth by the time of weaning from the sow.
5.9 Overdose (symptoms, emergency measures, antidotes)
No data.
5.10 Special warnings
No.
5.11 Withdrawal period
When using the drug according to the indicated scheme, the active substance and its decay products were not found in poultry meat.
Meat of cows and pigs, milk, eggs – 28 days.
Upon receipt of products before the specified period, they are disposed of or fed to unproductive animals, according to the conclusion of a veterinarian.
5.12 Special warnings for persons and service personnelFollow the rules for handling veterinary drugs.
- Pharmaceutical Features
6.1 Forms of incompatibility (basic)
No data.
6.2 Shelf life 2 years.
An aqueous solution of the drug must be used on the day of preparation.
6.3 Special storage measures
Dry, protected from light place at a temperature of 4 to 25 ° C.
6.4 Nature and composition of the primary packaging container
Glass bottles, 20, 50 and 100 ml.
6.5 Special precautions for handling unused drug or drug residues
Dispose of the unused product or its residues in accordance with current regulations.
- Name and location of the marketing authorization holder
OOO NPP Lugfarma
st. Kurchatova, d. 6, of. 9, Lugansk, Lugansk region, 91031, Ukraine
- Manufacturer name and location
Kharkiv State Biological Factory
per. Rustaveli, 4, Kharkov, Kharkov region, 61050, Ukraine
- Additional Information